Contrary to popular belief, it isn't how much money you make, how engrossed you are in your work, the work/life balance the job affords, or whether you feel what you do makes a difference in the world. While those things are certainly important, the single biggest determinant of on-the-job satisfaction is whether you get along with your boss and co-workers . I have several friends and a couple of relatives who have resigned from their jobs despite genuinely enjoying the work and being handsomely compensated. In each case, they either had a toxic boss or one or more co-workers who had a penchant for stabbing them on the back. Let's face it: No amount of money an employer throws at us -- whether it's $75,000 or $5 million a year -- can compensate for having to tolerate an abusive supervisor or conniving co-workers. Given that most of us spend 40 or more hours at the office each week, having to put up with such behavior can eventually take a serious toll on us -- physi...